Endophytic Fungi as a Source of Antibacterial Compounds-A Focus on Gram-Negative Bacteria.

ABSTRACT: Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical

SUBMITTER: Silva DPD 

PROVIDER: S-EPMC9687006 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature