Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.

ABSTRACT:

Background

No effective therapeutic agents for calcific aortic valve disease (CAVD) are available currently. Dietary supplementation has been proposed as a novel treatment modality for various diseases. As a flavanone, hesperetin is widely abundant in citrus fruits and has been proven to exert protective effects in multiple diseases. However, the role of hesperetin in CAVD remains unclear.

Methods

Human aortic valve interstitial cells (VICs) were isolated from aortic valve leaflets. A mouse model of aortic valve stenosis was constructed by direct wire injury (DWI). Immunoblotting, immunofluorescence staining, and flow cytometry were used to investigate the roles of sirtuin 7 (Sirt7) and nuclear factor erythroid 2-related factor 2 (Nrf2) in hesperetin-mediated protective effe

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9687039 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature