Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione in Campylobacter jejuni.

ABSTRACT: This work describes the synthesis and characterization of two metal complexes of the type [M(L₁)₂(phen)], where M = Pt²⁺ (complex I) or Pd²⁺ (complex II), L₁ = 5-amino-1,3,4-thiadiazole-2(3H)-thiolate and phen = 1,10-phenanthroline. The in vitro antibacterial activity of these complexes was investigated in isolation and synergistically with ciprofloxacin (CIP) and erythromycin (ERY) in three strains of Campylobacter jejuni (MIC = 32 mg/L for CIP and ERY), selected from a bank of 235 strains representative of three poultry exporting states of the country (A, B and C), previously analyzed for epidemiology and resistance to CIP and ERY. A total of 53/235 (22.55%) strains showed co-resistance to CIP and ERY. Isolated r

SUBMITTER: Lacerda ML 

PROVIDER: S-EPMC9687049 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature