Repurposable Drugs That Interact with Steroid Responsive Gene Targets for Inner Ear Disease.

ABSTRACT: Corticosteroids, oral or transtympanic, remain the mainstay for inner ear diseases characterized by hearing fluctuation or sudden changes in hearing, including sudden sensorineural hearing loss (SSNHL), Meniere's disease (MD), and autoimmune inner ear disease (AIED). Despite their use across these diseases, the rate of complete recovery remains low, and results across the literature demonstrates significant heterogeneity with respect to the effect of corticosteroids, suggesting a need to identify more efficacious treatment options. Previously, our group has cross-referenced steroid-responsive genes in the cochlea with published single-cell and single-nucleus transcriptome datasets to demonstrate that steroid-responsive differentially regulated genes are expressed in spiral ganglion neurons

SUBMITTER: Missner AA 

PROVIDER: S-EPMC9687275 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature