Changes to Urinary Proteome in High-Fat-Diet ApoE^-/- Mice.

ABSTRACT: Cardiovascular disease is currently the leading cause of death worldwide. Atherosclerosis is an important pathological basis of cardiovascular disease, and its early diagnosis is of great significance. Urine bears no need nor mechanism to be stable, so it accumulates many small changes and is therefore a good source of biomarkers in the early stages of disease. In this study, ApoE-/- mice were fed a high-fat diet for 5 months. Urine samples from the experimental group and control group (C57BL/6 mice fed a normal diet) were collected at seven time points. Proteomic analysis was used for comparison within the experimental group and for comparison between the experimental group and the control group. The results of the comparison within the experimental group showed a significant difference i

SUBMITTER: Hua Y 

PROVIDER: S-EPMC9687344 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature