Cumulative Effect Assessment of Common Genetic Variants on Prostate Cancer: Preliminary Studies.

ABSTRACT: Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. Genome Wide Association studies (GWASs) have generated multiple genetic variants associated with prostate cancer (PC) risk. Taking into account previously identified genetic susceptibility variants, the purpose of our study was to determine the cumulative association between four common SNPs and the overall PC risk. A total of 78 specimens from both PC and benign prostate hyperplasia (BPH) patients were included in the study. Genotyping of all selected SNPs was performed using the TaqMan assay. The association between each SNP and the PC risk was assessed individually and collectively. Analysis of the association between individual SNPs and PC risk revealed that only the rs4054823 polymorphis

SUBMITTER: Pavel AG 

PROVIDER: S-EPMC9687438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature