Recent Developments in Mycobacteria-Based Live Attenuated Vaccine Candidates for Tuberculosis.

ABSTRACT: Vaccination is an excellent approach to stimulating the host immune response and reducing human morbidity and mortality against microbial infections, such as tuberculosis (TB). Bacillus Calmette-Guerin (BCG) is the most widely administered vaccine in the world and the only vaccine approved by the World Health Organization (WHO) to protect against TB. Although BCG confers "protective" immunity in children against the progression of Mycobacterium tuberculosis (Mtb) infection into active TB, this vaccine is ineffective in protecting adults with active TB manifestations, such as multiple-, extensive-, and total-drug-resistant (MDR/XDR/TDR) cases and the co-existence of TB with immune-compromising health conditions, such as HIV infection or diabetes. Moreover, BCG can cause disease in in

SUBMITTER: Flores-Valdez MA 

PROVIDER: S-EPMC9687462 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature