Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent but still poorly understood clinical entity. Its current pathophysiological understanding supports a critical role of comorbidities and their chronic effect on cardiac function and structure. Importantly, despite the replication of some HFpEF phenotypic features, to this day, experimental models have failed to bring new effective therapies to the clinical setting. Thus, the direct investigation of HFpEF human myocardial samples may unveil key, and possibly human-specific, pathophysiological mechanisms. This study employed quantitative proteomic analysis by advanced mass spectrometry (SWATH-MS) to investigate signaling pathways and pathophysiological mechanisms in HFpEF. Protein-expression profiles were analyzed in

SUBMITTER: Sebastiao MJ 

PROVIDER: S-EPMC9687619 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature