Stem Cell- and Cell-Based Therapies for Ischemic Stroke.

ABSTRACT: Stroke is the second cause of disability worldwide as it is expected to increase its incidence and prevalence. Despite efforts to increase the number of patients eligible for recanalization therapies, a significant proportion of stroke survivors remain permanently disabled. This outcome boosted the search for efficient neurorestorative methods. Stem cells act through multiple pathways: cell replacement, the secretion of growth factors, promoting endogenous reparative pathways, angiogenesis, and the modulation of neuroinflammation. Although neural stem cells are difficult to obtain, pose a series of ethical issues, and require intracerebral delivery, mesenchymal stem cells are less immunogenic, are easy to obtain, and can be transplanted via intravenous, intra-arterial, or intranasal routes

SUBMITTER: Nistor-Cseppento DC 

PROVIDER: S-EPMC9687728 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature