Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities.

ABSTRACT: Amniotic fluid (AF) provides critical biological and physical support for the developing fetus. While AF is an excellent source of progenitor cells with regenerative properties, recent investigations indicate that cell-free AF (cfAF), which consists of its soluble components and extracellular vesicles, can also stimulate regenerative and reparative activities. This review summarizes published fundamental, translational, and clinical investigations into the biological activity and potential use of cfAF as a therapeutic agent. Recurring themes emerge from these studies, which indicate that cfAF can confer immunomodulatory, anti-inflammatory, and pro-growth characteristics to the target cells/tissue with which they come into contact. Another common observation is that cfAF seems to promote a

SUBMITTER: Bowen CM 

PROVIDER: S-EPMC9687956 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature