Genetic Variants of the TERT Gene and Telomere Length in Obstructive Sleep Apnea.

ABSTRACT:

Introduction

Obstructive sleep apnea (OSA) is a worldwide breathing disorder that has been diagnosed globally in almost 1 billion individuals aged 30-69 years. It is characterized by repeated upper airway collapses during sleep. Telomerase reverse transcriptase (TERT) is involved in the prevention of telomere shortening. This prospective, observational study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of TERT and the severity of OSA, taking into account hypertension and diabetes prevalence.

Methods

A total of 149 patients with OSA were diagnosed using one-night video-polysomnography based on the American Academy of Sleep Medicine guidelines. The TERT SNPs and telomere length (TL) were detected using real-time quantitative polymerase c

SUBMITTER: Macek P 

PROVIDER: S-EPMC9688013 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature