Leveraging Accelerometry as a Prognostic Indicator for Increase in Opioid Withdrawal Symptoms.

ABSTRACT: Treating opioid use disorder (OUD) is a significant healthcare challenge in the United States. Remaining abstinent from opioids is challenging for individuals with OUD due to withdrawal symptoms that include restlessness. However, to our knowledge, studies of acute withdrawal have not quantified restlessness using involuntary movements. We hypothesized that wearable accelerometry placed mid-sternum could be used to detect withdrawal-related restlessness in patients with OUD. To study this, 23 patients with OUD undergoing active withdrawal participated in a protocol involving wearable accelerometry, opioid cues to elicit craving, and non-invasive Vagal Nerve Stimulation (nVNS) to dampen withdrawal symptoms. Using accelerometry signals, we analyzed how movements correlated with changes in ac

SUBMITTER: Lambert TP 

PROVIDER: S-EPMC9688173 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature