Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification

ABSTRACT:

Simple Summary

The resistance formation of cancer cells to chemotherapeutic drugs is one of the main reasons for the failure of cancer therapy. In order to combat drug resistance and improve the efficacy of chemotherapeutic drugs, we studied the role of the multifaceted hsa-miR-200c in different tumor types. We identified hsa-miR-200c as an important player regulating phase II detoxification and thus sensitizing cells to chemotherapeutics and reverse drug resistance. In a xenograft mouse experiment, the mutual expression of hsa-miR-200c and chemotherapeutic treatment led to a regression of tumor size and eventually to the survival of 60% of the mice. These findings highlight hsa-miR-200c both as a potential prognostic marker for chemotherapy and as a novel therapeutic option in ca

SUBMITTER: Kohler B 

PROVIDER: S-EPMC9688189 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature