Antitumor Activity of Simvastatin in Preclinical Models of Mantle Cell Lymphoma.

ABSTRACT:

Background

Mantle cell lymphoma (MCL) is a rare and aggressive subtype of B-cell non-Hodgkin lymphoma that remains incurable with standard therapy. Statins are well-tolerated, inexpensive, and widely prescribed as cholesterol-lowering agents to treat hyperlipidemia and to prevent cardiovascular diseases through the blockage of the mevalonate metabolic pathway. These drugs have also shown promising anti-cancer activity through pleiotropic effects including the induction of lymphoma cell death. However, their potential use as anti-MCL agents has not been evaluated so far.

Aim

The present study aimed to investigate the activity of simvastatin on MCL cells.

Methods

We evaluated the cytotoxicity of simvastatin in MCL cell lines by CellTiter-Glo and lactate dehydrogenase (L

SUBMITTER: Santos JC 

PROVIDER: S-EPMC9688202 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature