A Novel m7G-Related Gene Signature Predicts the Prognosis of Colon Cancer.

ABSTRACT: Colon cancer (CC), one of the most common malignancies worldwide, lacks an effective prognostic prediction biomarker. N7-methylguanosine (m7G) methylation is a common RNA modification type and has been proven to influence tumorigenesis. However, the correlation between m7G-related genes and CC remains unclear. The gene expression levels and clinical information of CC patients were downloaded from public databases. Twenty-nine m7G-related genes were obtained from the published literature. Via unsupervised clustering based on the expression levels of m7G-related genes, CC patients were divided into three m7G clusters. Based on differentially expressed genes (DEGs) from the above three groups, CC patients were further divided into three gene clusters. The m7G score, a prognostic model, was es

SUBMITTER: Chen J 

PROVIDER: S-EPMC9688272 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature