Timing of Systemic Steroids and Neurodevelopmental Outcomes in Infants < 29 Weeks Gestation.

ABSTRACT:

Objective

To determine the association between postnatal age (PNA) at first administration of systemic postnatal steroids (sPNS) for bronchopulmonary dysplasia (BPD) and mortality or significant neurodevelopmental impairment (sNDI) at 18-24 months corrected age (CA) in infants < 29 weeks' gestation.

Methods

Data from the Canadian Neonatal Network and Canadian Neonatal Follow-up Network databases were used to conduct this retrospective cohort study. Infants exposed to sPNS for BPD after the 1st week of age were included and categorized into 8 groups based on the postnatal week of the exposure. The primary outcome was a composite of mortality or sNDI. A multivariable logistic regression model adjusting for potential confounders was used to determine the association between

SUBMITTER: Kandraju H 

PROVIDER: S-EPMC9688446 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature