Transcriptome-Wide Study of mRNAs and lncRNAs Modified by m⁶A RNA Methylation in the Longissimus Dorsi Muscle Development of Cattle-Yak.

ABSTRACT: Cattle-yak is a hybrid F₁ generation of cattle and yak, which has a history of more than 3000 years and has shown better production performance and higher economic benefits than those of yaks. However, up to now, there has been no study on the transcriptome-wide m⁶A methylation profile of bovine skeletal muscle and its potential biological function during muscle development. Here, we observed significant changes in the expression levels of muscle-related marker genes and methylation-related enzymes during the development of cattle-yak, and the overall m⁶A content in the Longissimus dorsi muscle of 18-month-old cattle-yak decreased significantly. A total of 36,602 peaks, 11,223 genes and 8388 lncRNAs were identified in the two groups, including 2989 d

SUBMITTER: Huang C 

PROVIDER: S-EPMC9688506 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature