Radioresistance Mechanisms in Prostate Cancer Cell Lines Surviving Ultra-Hypo-Fractionated EBRT: Implications and Possible Clinical Applications

ABSTRACT:

Simple Summary

Radiotherapy is an option for curing localized and locally advanced prostate cancer. However, radioresistance can occur, determining treatment failure and poor prognosis. Herein, we developed a model of radio-resistant prostate cancer cells by irradiating the bone metastasis-derived PC3 highly metastatic prostate cancer cell line and the brain-derived moderately metastatic DU-145 prostate cancer cell line, both castration-resistant. Ultra-hypo-fractionated radiotherapy was used, with doses and intervals similar to the ones used in clinical practice. These in vitro models were tested to gain information on the molecular mechanisms used by prostate cancer cells to survive radiation-induced death. Results from bioassays and molecular assays show that in the highly meta

SUBMITTER: Sideri S 

PROVIDER: S-EPMC9688510 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature