Advanced Lab-on-Fiber Optrodes Assisted by Oriented Antibody Immobilization Strategy.

ABSTRACT: Lab-on-fiber (LoF) optrodes offer several advantages over conventional techniques for point-of-care platforms aimed at real-time and label-free detection of clinically relevant biomarkers. Moreover, the easy integration of LoF platforms in medical needles, catheters, and nano endoscopes offer unique potentials for in vivo biopsies and tumor microenvironment assessment. The main barrier to translating the vision close to reality is the need to further lower the final limit of detection of developed optrodes. For immune-biosensing purposes, the assay sensitivity significantly relies on the capability to correctly immobilize the capture antibody in terms of uniform coverage and correct orientation of the bioreceptor, especially when very low detection limits are requested as in the case of ca

SUBMITTER: Ucci S 

PROVIDER: S-EPMC9688615 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature