Prognosis-Related Molecular Subtypes and Immune Features Associated with Hepatocellular Carcinoma.

ABSTRACT: Bioinformatics tools were used to identify prognosis-related molecular subtypes and biomarkers of hepatocellular carcinoma (HCC). Differential expression analysis of four datasets identified 3330 overlapping differentially expressed genes (DEGs) in the same direction in all four datasets. Those genes were involved in the cell cycle, FOXO signaling pathway, as well as complement and coagulation cascades. Based on non-negative matrix decomposition, two molecular subtypes of HCC with different prognoses were identified, with subtype C2 showing better overall survival than subtype C1. Cox regression and Kaplan-Meier analysis showed that 217 of the overlapping DEGs were closely associated with HCC prognosis. The subset of those genes showing an area under the curve >0.80 was used to construct r

SUBMITTER: Ye J 

PROVIDER: S-EPMC9688639 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature