Pro-Inflammatory Oral Microbiota in Juvenile Spondyloarthritis: A Pilot Study.

ABSTRACT: The role of the microbiota in the pathogenesis of arthritis is gaining increasing attention. While multiple studies have queried the intestinal microbiota, very few have analyzed the contents of the oral microbiota. In this pilot study, we obtained salivary and sub-gingival specimens from a cohort of six healthy controls and five children with well-controlled spondyloarthritis (SpA) and performed 16S sequencing on bacteria obtained from both habitats. The Quantitative Insight into Microbial Ecology tool suite was used to generate operational taxonomic units, Phyloseq was used for diversity analyses, and DeSeq2 was used to compare abundances while adjusting for multiple comparisons. A repeat specimen was obtained from one subject during a flare. Clustering based upon diagnosis was observed

SUBMITTER: Stoll ML 

PROVIDER: S-EPMC9688681 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature