Histone Chaperones and Digestive Cancer: A Review of the Literature.

ABSTRACT:

Background

The global burden of digestive cancer is expected to increase. Therefore, crucial for the prognosis of patients with these tumors is to identify early diagnostic markers or novel therapeutic targets. There is accumulating evidence connecting histone chaperones to the pathogenesis of digestive cancer. Histone chaperones are now broadly defined as a class of proteins that bind histones and regulate nucleosome assembly. Recent studies have demonstrated that multiple histone chaperones are aberrantly expressed and have distinct roles in digestive cancers.

Objective

The purpose of this review is to present the current evidence regarding the role of histone chaperones in digestive cancer, particularly their mechanism in the development and progression of esophageal, gas

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9688693 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature