Targeting PTEN Regulation by Post Translational Modifications.

ABSTRACT: Phosphatidylinositol-3,4,5-triphosphate (PIP₃) is a lipidic second messenger present at very low concentrations in resting normal cells. PIP₃ levels, though, increase quickly and transiently after growth factor addition, upon activation of phosphatidylinositol 3-kinase (PI3-kinase). PIP₃ is required for the activation of intracellular signaling pathways that induce cell proliferation, cell migration, and survival. Given the critical role of this second messenger for cellular responses, PIP₃ levels must be tightly regulated. The lipid phosphatase PTEN (phosphatase and tensin-homolog in chromosome 10) is the phosphatase responsible for PIP₃ dephosphorylation to PIP₂. PTEN tumor suppressor is frequently inactivated in endometri

SUBMITTER: Gonzalez-Garcia A 

PROVIDER: S-EPMC9688753 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature