The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers.

ABSTRACT: The human UDP-glycosyltransferase (UGTs) superfamily has a critical role in the metabolism of anticancer drugs and numerous pro/anti-cancer molecules (e.g., steroids, lipids, fatty acids, bile acids and carcinogens). Recent studies have shown wide and abundant expression of UGT genes in human cancers. However, the extent to which UGT genes acquire somatic mutations within tumors remains to be systematically investigated. In the present study, our comprehensive analysis of the somatic mutation profiles of 10,069 tumors from 33 different TCGA cancer types identified 3427 somatic mutations in UGT genes. Overall, nearly 18% (1802/10,069) of the assessed tumors had mutations in UGT genes with huge variations in mutation frequency across different cancer types, rangin

SUBMITTER: Hu DG 

PROVIDER: S-EPMC9688768 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature