Identification of Factors Driving Doxorubicin-Resistant Ewing Tumor Cells to Survival.

ABSTRACT:

Background

Ewing sarcoma (ES) cells exhibit extreme plasticity that contributes to the cell's survival and recurrence. Although multiple studies reveal various signaling pathways mediated by the EWSR1/FLI1 fusion, the specific transcriptional control of tumor cell resistance to doxorubicin is unknown. Understanding the molecular hubs that contribute to this behavior provides a new perspective on valuable therapeutic options against tumor cells.

Methods

Single-cell RNA sequencing and LC-MS/MS-based quantitative proteomics were used.

Results

A goal of this study was to identify protein hubs that would help elucidate tumor resistance which prompted ES to relapse or metastasize. Several differentially expressed genes and proteins, including adhesion, cytoskeletal, and sig

SUBMITTER: Yakushov S 

PROVIDER: S-EPMC9688843 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature