Polygenic Risk Scores Associated with Tumor Immune Infiltration in Common Cancers.

ABSTRACT: It is largely unknown whether genetic susceptibility contributes to tumor immune infiltration in common cancers. We systematically investigated the association between polygenic risk scores (PRSs) and tumor immune infiltration in common cancers. First, we constructed a PRS for common cancers using the risk variants identified in previous genome-wide association studies. Then, we analyzed 139 immune traits predicted by previous studies by examining gene expression data in tumor tissues from The Cancer Genome Atlas (TCGA). We applied regression analyses to evaluate the associations between PRS and immune traits for each cancer overall and stratified by stage, including 2160 pathologically confirmed cases of breast, colorectal, lung, ovarian, pancreatic, and prostate cancers in the White popu

SUBMITTER: Choi J 

PROVIDER: S-EPMC9688863 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature