PD-L1 Activity Is Associated with Partial EMT and Metabolic Reprogramming in Carcinomas.

ABSTRACT: Immune evasion and metabolic reprogramming are hallmarks of cancer progression often associated with a poor prognosis and frequently present significant challenges for cancer therapies. Recent studies have highlighted the dynamic interaction between immunosuppression and the dysregulation of energy metabolism in modulating the tumor microenvironment to promote cancer aggressiveness. However, a pan-cancer association among these two hallmarks, and a potent common driver for them-epithelial-mesenchymal transition (EMT)-remains to be done. This meta-analysis across 184 publicly available transcriptomic datasets as well as The Cancer Genome Atlas (TCGA) data reveals that an enhanced PD-L1 activity signature along with other immune checkpoint markers correlate positively with a partial EMT and

SUBMITTER: Muralidharan S 

PROVIDER: S-EPMC9688938 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature