CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction.

ABSTRACT:

Background

Cervical cancer (CC) is a common cancer in female, which is associated with problems like poor prognosis. Circular RNA (circRNA) is a kind of competing endogenous RNA (ceRNA) that has an important role in regulating microRNA (miRNA) in many cancers. The regulatory mechanisms of CC immune microenvironment and the transcriptome level remain to be fully explored.

Methods

In this study, we constructed the ceRNA network through the interaction data and expression matrix of circRNA, miRNA and mRNA. Meanwhile, based on the gene expression matrix, CIBERSORT algorithm was used to reveal contents of tumor-infiltrating immune cells (TIICs). Then, we screened prognostic markers based on ceRNA network and immune infiltration and constructed two nomograms. In order to find immu

SUBMITTER: Guo X 

PROVIDER: S-EPMC9689098 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature