Urinary Protein Profiling for Potential Biomarkers of Chronic Kidney Disease: A Pilot Study.

ABSTRACT: Proteinuria is a risk factor for chronic kidney disease (CKD) progression and associated complications. However, there is insufficient information on individual protein components in urine and the severity of CKD. We aimed to investigate urinary proteomics and its association with proteinuria and kidney function in early-stage CKD and in healthy individuals. A 24 h urine sample of 42 individuals (21-CKD and 21-healthy individuals) was used for mass spectrometry-based proteomics analysis. An exponentially modified protein abundance index (emPAI) was calculated for each protein. Data were analyzed by Mascot software using the SwissProt database and bioinformatics tools. Overall, 298 unique proteins were identified in the cohort; of them, 250 proteins belong to the control group with median (

SUBMITTER: Gaipov A 

PROVIDER: S-EPMC9689510 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature