An Explanation of Exceptions from Chargaff's Second Parity Rule/Strand Symmetry of DNA Molecules.

ABSTRACT: In this article, we show that mono/oligonucleotide quadruplets, as basic structures of DNA, along with our classification of trinucleotides, disclose an organization of genomes based on purine-pyrimidine symmetry. Moreover, the structure and stability of DNA are influenced by the Watson-Crick pairing and the natural law of DNA creation and conservation, according to which the same mono- or oligonucleotide insertion must be inserted simultaneously into both strands of DNA. Taken together, they lead to quadruplets with central mirror symmetry and bidirectional DNA strand orientation and are incorporated into Chargaff's second parity rule (CSPR). Performing our quadruplet frequency analysis of all human chromosomes and of Neuroblastoma BreakPoint Family (NBPF) genes, which code Olduvai protei

SUBMITTER: Rosandic M 

PROVIDER: S-EPMC9689577 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature