Sex and Age Influence on Association of CYP450 Polymorphism with Midazolam Levels in Critically Ill Children.

ABSTRACT: Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The present study aimed to determine the sex and age influence on association of CYP450 polymorphism with midazolam levels in critically ill children. Seventy-two DNA samples were genotyped by real-time PCR. Children ≤ five years of age who carry the rs776746 (T) allele in CYP3A5 gene were associated with lower plasma midazolam levels. The concentration median in patients was 0.0 ng/mL, while in patients with the normal (C) allele, it was 438.17 ng/mL (Q₂₅ 135.75-Q₇₅ 580.24), p = 0.005. The midazolam plasmatic concentration in female patients with the minor (T) allele was 0.0 ng/mL (Q₂₅0.00-Q₇₅204.3), while in patients with t

SUBMITTER: Flores-Perez C 

PROVIDER: S-EPMC9689687 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature