Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a novel class of epigenetic regulators that participate in leukemogenesis. However, their roles in leukemia relapse after transplantation remain unclear.

Methods

We defined the circRNAs profile of the bone-marrow-enriched CD34⁺ cells from ten acute myeloid leukemia (AML) patients after transplantation (five relapse [RE] and five continuous complete remission [CR]) and four healthy controls (HCs) by RNA-seq. Differentially expressed circRNAs were validated using real-time quantitative polymerase chain reaction (RT-qPCR) in an independent cohort of six AML patients with pairwise samples at diagnosis and at relapse and six controls.

Results

The bioinformatics analysis revealed a distinct circRNAs profile in relapse patie

SUBMITTER: Zhao F 

PROVIDER: S-EPMC9689715 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature