Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach.
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ABSTRACT:
SUBMITTER: Rajagopal S
PROVIDER: S-EPMC9690332 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Inferring <i>bona fide</i> Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach.
Rajagopal Shalini S Sharma Akanksha A Simlot Anita A Mathur Praveen P Mehta Sudhir S Mehta Sumita S Naravula Jalaja J Medicherla Krishna Mohan KM Kumar Anil A Kanga Uma U Suravajhala Renuka R Bhandari Ramji Kumar RK Nair Bipin G BG Kishor P B Kavi PBK Suravajhala Prashanth P
Genes 20221109 11
Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease phenotypes, <i>viz</i>., myocardial infarction, renal failure and prostate cancer. We sought to ask whether or not any DEGs harbor pathogenic variants common in these conditions, attempt to bridge the ...[more]
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