Identification of Ferroptosis-Related Genes in Schizophrenia Based on Bioinformatic Analysis.

ABSTRACT: The purpose of this study is to explore the correlation between ferroptosis-related genes and schizophrenia in order to explore the new direction of diagnosis and treatment of schizophrenia. We screened the datasets related to schizophrenia from the Gene Expression Comprehensive Database (GEO) and obtained ferroptosis-related genes from the FerrDB database. Bioinformatics methods were used to analyze differentially expressed genes (DEGs) and genes associated with ferroptosis-related between schizophrenia patients and healthy controls. On this basis, the hub genes were finally screened by enrichment analysis and PPI interaction analysis. Hub genes associated with ferroptosis were validated using other schizophrenia datasets in the GEO database. Finally, the hub gene-microRNA (miRNA), gene-t

SUBMITTER: Feng S 

PROVIDER: S-EPMC9690569 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature