General Designs Reveal Distinct Codes in Protein-Coding and Non-Coding Human DNA.

ABSTRACT: This study seeks to investigate distinct signatures and codes within different genomic sequence locations of the human genome. The promoter and other non-coding regions contain sites for the binding of biological particles, for processes such as transcription regulation. The specific rules and sequence codes that govern this remain poorly understood. To derive these (codes), the general designs of sequence are investigated. Genomic signatures are a powerful tool for assessing the general designs of sequence, and cross-comparing different genomic regions for their distinct sequence properties. Through these genomic signatures, the relative non-random properties of sequences are also assessed. Furthermore, a binary components analysis is carried out making use of information theory ideas, to

SUBMITTER: Cohen D 

PROVIDER: S-EPMC9690640 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature