Association between IL-1 Gene Polymorphisms and Stage III Grade B Periodontitis in Polish Population.

ABSTRACT: Periodontitis is a chronic multifactorial inflammatory disease originating from microbial, environmental and genetic factors. The present study aimed to find an association of genetic polymorphisms at IL-1A^-889 and IL-1B⁺³⁹⁵³ loci in Polish patients with stage III grade B periodontitis and periodontally healthy subjects. Fifty patients with stage III grade B periodontitis (tests) and thirty-five periodontally healthy controls were included in the study. To determine IL-1A and IL-1B gene polymorphisms, buccal swab-derived DNA obtained by means of the GenoType PST test was used. There were no statistically significant differences regarding the prevalence of IL-1A^-889 or IL-1B⁺³⁹⁵³ alleles between groups. The frequencies of different IL-1A^-889<

SUBMITTER: Brodzikowska A 

PROVIDER: S-EPMC9690736 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature