Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review.

ABSTRACT:

Background

Sarcomas comprise approximately 1% of all human malignancies; treatment resistance is one of the major reasons for the poor prognosis of sarcomas. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs, and circular RNAs, are important molecules involved in the crosstalk between resistance to chemotherapy, targeted therapy, and radiotherapy via various pathways.

Methods

We searched the PubMed (MEDLINE) database for articles regarding sarcoma-associated ncRNAs from inception to August 17, 2022. Studies investigating the roles of host-derived miRNAs, long ncRNAs, and circular RNAs in sarcoma were included. Data relating to the roles of ncRNAs in therapeutic regulation and their applicability as biomarkers for predicting the thera

SUBMITTER: Chen HH 

PROVIDER: S-EPMC9691005 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature