In silico analysis of alternative splicing events implicated in intracellular trafficking during B-lymphocyte differentiation.

ABSTRACT: There are multiple regulatory layers that control intracellular trafficking and protein secretion, ranging from transcriptional to posttranslational mechanisms. Finely regulated trafficking and secretion is especially important for lymphocytes during activation and differentiation, as the quantity of secretory cargo increases once the activated cells start to produce and secrete large amounts of cytokines, cytotoxins, or antibodies. However, how the secretory machinery dynamically adapts its efficiency and specificity in general and specifically in lymphocytes remains incompletely understood. Here we present a systematic bioinformatics analysis to address RNA-based mechanisms that control intracellular trafficking and protein secretion during B-lymphocyte activation, and differentiation, w

SUBMITTER: Ostwaldt F 

PROVIDER: S-EPMC9691287 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature