Examining the effects of Salmonella phage on the caecal microbiota and metabolome features in Salmonella-free broilers.

ABSTRACT: Bacteriophages selectively infect and kill their target bacterial host, being a promising approach to controlling zoonotic bacteria in poultry production. To ensure confidence in its use, fundamental questions of safety and toxicity monitoring of phage therapy should be raised. Due to its high specificity, a minimal impact on the gut ecology is expected; however, more in-depth research into key parameters that influence the success of phage interventions has been needed to reach a consensus on the impact of bacteriophage therapy in the gut. In this context, this study aimed to investigate the interaction of phages with animals; more specifically, we compared the caecum microbiome and metabolome after a Salmonella phage challenge in Salmonella-free broilers, evaluating the rol

SUBMITTER: Lorenzo-Rebenaque L 

PROVIDER: S-EPMC9691336 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature