Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology.

ABSTRACT: Numerous shown consequences of age-related hearing loss have been unveiled; however, the relationship of the cortical and subcortical structures of the auditory pathway with aging is not well known. Investigations into neural structure analysis remain sparse due to difficulties of doing so in animal models; however, recent technological advances have been able to achieve a resolution adequate to perform such studies even in the small mouse. We utilize 12 members of the BXD family of recombinant inbred mice and aged separate cohorts. Utilizing novel magnetic resonance histology imaging techniques, we imaged these mice and generated high spatial resolution three dimensional images which were then comprehensively labeled. We completed volumetric analysis of 12 separate regions of interest spe

SUBMITTER: Du EY 

PROVIDER: S-EPMC9691338 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature