Longitudinal Analysis of Patient-Reported Cognitive Function in Multiple Myeloma.

ABSTRACT:

Background

Cancer-related cognitive impairment (CRCI) has been largely unstudied in patients with multiple myeloma (MM). This study describes patient-reported cognition over time and patient factors associated with adverse cognitive outcomes in MM.

Methods

Participants enrolled in a registry in which they completed a geriatric assessment at study entry, and 3 & 6 months after entry. Cognitive function was assessed using the EORTC QLQ-C30 Cognitive Function subscale, with CRCI defined as scores < 75. Generalized estimating equation (GEE) models were used to fit longitudinal models to investigate differences by group and differences in changes over time by group, with adjustment for time since diagnosis.

Results

One hundred and four adults with MM had mean age of 67 yea

SUBMITTER: Yusuf ARS 

PROVIDER: S-EPMC9691560 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature