Unique prediction of developmental psychopathology from genetic and familial risk.

ABSTRACT:

Background

Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth.

Methods

We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n = 5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study^SM . Associations were measured both with and without accounting for shared variance across measures of genetic risk.

Results

When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely ass

SUBMITTER: Loughnan RJ 

PROVIDER: S-EPMC9691563 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature