Association of Intra-individual Differences in Estimated GFR by Creatinine Versus Cystatin C With Incident Heart Failure.

ABSTRACT:

Rationale & objective

Lower estimated glomerular filtration rate (eGFR) is associated with heart failure (HF) risk. However, eGFR based on cystatin C (eGFR_cys) and creatinine (eGFR_cr) may differ substantially within an individual. The clinical implications of these differences for risk of HF among persons with chronic kidney disease (CKD) are unknown.

Study design

Prospective cohort study.

Setting & participants

4,512 adults with CKD and without prevalent HF who enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Exposure

Difference in GFR estimates (eGFR_diff; ie, eGFR_cys minus eGFR_cr).

Outcome

Incident HF hospitalization.

Analytical approach

Fine-Gray proportional subhazards regr

SUBMITTER: Chen DC 

PROVIDER: S-EPMC9691565 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature