Clinical and Genomic Characterization of Interval Colorectal Cancer in 3 Prospective Cohorts.

ABSTRACT:

Background & aims

Interval colorectal cancers (CRCs), cancers diagnosed after a screening/surveillance examination in which no cancer is detected, and before the date of next recommended examination, reflect an unprecedented challenge in CRC detection and prevention. To better understand this poorly characterized CRC variant, we examined the clinical and mutational characteristics of interval CRCs in comparison with screen detected CRCs.

Methods

We included 1175 CRCs documented in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial and 3661 CRCs in the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS). Multivariable Cox models were performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of death risk. Whole

SUBMITTER: Yang K 

PROVIDER: S-EPMC9691567 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature