Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics.

ABSTRACT:

Objective

High BMI is associated with many comorbidities and mortality. This study aimed to elucidate the overall clinical risk of obesity using a genome- and phenome-wide approach.

Methods

This study performed a phenome-wide association study of BMI using a clinical cohort of 736,726 adults. This was followed by genetic association studies using two separate cohorts: one consisting of 65,174 adults in the Electronic Medical Records and Genomics (eMERGE) Network and another with 405,432 participants in the UK Biobank.

Results

Class 3 obesity was associated with 433 phenotypes, representing 59.3% of all billing codes in individuals with severe obesity. A genome-wide polygenic risk score for BMI, accounting for 7.5% of variance in BMI, was associated with 296 clinical d

SUBMITTER: Robinson JR 

PROVIDER: S-EPMC9691570 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature