The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease.

ABSTRACT: The pathogenesis of diabetic kidney disease (DKD) involves multifactorial processes that converge to initiate and advance the disease. Although DKD is not typically classified as an inflammatory glomerular disease, mounting evidence supports the involvement of kidney inflammation as a key contributor in DKD pathogenesis, particularly through macrophages. However, detailed identification and corresponding phenotypic changes of macrophages in DKD remain poorly understood. To capture the gene expression changes in specific macrophage cell subsets in early DKD, we performed single-cell transcriptomic analysis of CD45-enriched kidney immune cells from type 1 diabetic OVE26 mice at two time points during the disease development. We also undertook a focused analysis of mononuclear phagocytes (mac

SUBMITTER: Fu J 

PROVIDER: S-EPMC9691617 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature