Designing metal chelates of halogenated sulfonamide Schiff bases as potent nonplatinum anticancer drugs using spectroscopic, molecular docking and biological studies.

ABSTRACT: In this contribution, five Ni(II) complexes have been synthesized from sulfonamide-based Schiff bases (SB¹-SB⁵) that comprise bromo or iodo substituents in the salicylidene moiety. The chemical structures of these compounds were extensively elucidated by different analytical and physicochemical studies. All ligands act as bidentate chelators with ON binding mode yielding octahedral, square planar, or tetrahedral geometries. The phenolic OH at δ 12.80 ppm in the free Schiff base SB² vanishes in the ¹H NMRspectrum of diamagnetic complex [Ni(SB²-H)₂] favoring the OH deprotonation prior to the chelation with Ni(II) ion. The appearance of twin molecular ion peaks ([M - 1]⁺ and [M + 1]⁺) is due to the presenc

SUBMITTER: Elsamra RMI 

PROVIDER: S-EPMC9691640 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature