C-reactive protein and coronary atheroma regression following statin therapy: A meta-regression of randomized controlled trials.

ABSTRACT:

Objective

Several clinical trials have indicated that statins stabilize and reverse atherosclerotic plaque. However, different studies have provided inconsistent findings regarding mechanisms and influencing factors of plaque regression under statin therapy. Apart from lipid-lowering effect, statins have pleiotropic effects including anti inflammation in humans. In this study, meta-analysis and meta-regression were used to determine the effects of statin medications on coronary plaque volume. Meanwhile, to assess whether statins promote plaque regression effect was related to their anti-inflammatory ability, the impact of CRP/hsCRP reduction during statin therapy on plaque regression was investigated.

Methods

Up to June 15, 2022, a systematic PubMed, EMBASE, and Cochrane sea

SUBMITTER: Gao D 

PROVIDER: S-EPMC9691666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature