Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.

ABSTRACT: Exercise results in mechanical loading of the bone and stimulates energy expenditure in the adipose tissue. It is therefore likely that the bone secretes factors to communicate with adipose tissue in response to mechanical loading. Interleukin (IL)-11 is known to be expressed in the bone, it is upregulated by mechanical loading, enhances osteogenesis and suppresses adipogenesis. Here, we show that systemic IL-11 deletion (IL-11^-/-) results in reduced bone mass, suppressed bone formation response to mechanical loading, enhanced expression of Wnt inhibitors, and suppressed Wnt signaling. At the same time, the enhancement of bone resorption by mechanical unloading was unaffected. Unexpectedly, IL-11^-/- mice have increased systemic adiposity and glucose intolerance. Osteo

SUBMITTER: Dong B 

PROVIDER: S-EPMC9691688 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature