The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula.

ABSTRACT: The mu opioid receptor (MOR) and the orphan GPR151 receptor are inhibitory G protein coupled receptors that are enriched in the habenula, a small brain region involved in aversion processing, addiction and mood disorders. While MOR expression in the brain is widespread, GPR151 expression is restricted to the habenula. In a previous report, we created conditional ChrnB4-Cre × Oprm1^fl/fl (so-called B4MOR) mice, where MORs are deleted specifically in Chrnb4-positive neurons restricted to the habenula, and shown a role for these receptors in naloxone aversion. Here we characterized the implication of habenular MORs in social behaviors. B4MOR^-/- mice and B4MOR^+/+ mice were compared in several social behavior measures, including the chronic social stress defeat (

SUBMITTER: Allain F 

PROVIDER: S-EPMC9691715 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature